December 2024

The gut microbiota and derived metabolites play a key role in regulating host physiology. Diet is identified as a key regulatory factor of the microbiota composition and, potentially, of subsequent functionali…The gut microbiota and derived metabolites play a key role in regulating host physiology. Diet is identified as a key regulatory factor of the microbiota […]

Pork is currently a major part of Danish food export and is also a key dietary source of protein across the world. Industrial pork production, however, comes with high antibiotic usage in many countries, inclu…Pork is currently a major part of Danish food export and is also a key dietary source of protein across the

The instructor has been engaged in the research of cerebral hemorrhage for many years, and summarized the methods of scalp acupuncture treatment of cerebral hemorrhage. The purpose of this study was to investigate the mechanism of acupuncture “Baihui” (DU20) penetrating “Qubin” (GB7) RhoA/ROCK II/MLC 2 signaling pathway on caveolae, an important component of the blood–brain

Esophageal strictures following esophageal atresia repair are a source of significant morbidity. To test new therapeutic approaches, we designed a piglet model of esophageal stricture by resecting variable lengths of esophagus with subsequent re-anastomosis. This study describes the model and validates its physiologic impact by blinded analysis of the weight gains of the piglets. A

Heterozygous low density lipoprotein receptor hamsters treated with STZ developed diabetic spontaneous hypertriglyceridemia, providing a useful model to study human diabetes complicated with hyperlipidemia. Abstract Hypertriglyceridemia (HTG) often accompanies diabetes and is considered a risk factor for diabetic vascular complications. However, inducing diabetic HTG typically requires high-fat diets in certain animal models. Leveraging our newly

Primary rabbit bone marrow mesenchymal stem cells (RBMSCs) were isolated and immortalized via retroviral expression of SV40 Large T antigen. We studied the ALP expression level and calcium deposition in bone morphogenetic protein 9 (BMP9)-induced immortalized cells in vitro. There was a synergy with BMP9 and GelMA hydrogel in inducing osteogenic differentiation of the iRBMSCs in vivo.

Xenograft-bearing immunodeficient mice are susceptible to developing unwanted disorders primarily irrelevant to nature of the xenografted tumor; and if get involved with such disorders, they do not produce reliable results, inevitably confounding the research outputs. This article reviews clinical signs of common unwanted disorders in experimental immunodeficient mice, and how to examine and report them.

Hemodynamic measurements improve the quality and certainty of the data obtained Abstract The present study aims to establish a reproducible large animal experimental unit using a minipig model to monitor cardiac function changes. A 90-min closed-chest balloon occlusion of the left anterior descending branch of the coronary artery was used to induce myocardial infarction in

Using chronic social defeat stress cage apparatus, the model mice exhibited characteristic behaviors resembling depression, including a significant decrease in preference for sugar-water, a notable reduction in the time spent sniffing female urine, a prolonged delay in initiating feeding, a substantial decrease in total distance traveled, residence time, and entries into the central zone in

Procedure for Surgical Internal Immobilization Modeling. After intraperitoneal anesthesia, the rat was placed on the operating table (A). In the lateral decubitus position, a longitudinal skin incision of approximately 3 cm was made along the inferior edge of the scapula, perpendicular to the spine of the scapula (B). After exposing the scapula and humerus (C), two